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It proved difficult to differentiate between the beneficial effects of recovery from depression and the possible adverse drug effects on sexual activity. Two patients dropped out of the study because of supposed sexual side-effects--a male with ejaculatory difficulties and a female with orgasmic impotence. Fifty-four patients completed the sexual questionnaire and a four-week course of clomipramine. There were nineteen males and thirty-five females. Clomipramine therapy seemed to have advantageous and disadvantageous effects. The advantageous effects were probably associated with improvement in depressive illness.
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Antidepressants increased the risk compared to placebo of suicidal thinking and behavior suicidality in children, adolescents, and young adults in short-term studies of anafranil 5mg depressive disorder MDD and other psychiatric disorders. Anyone considering the use of clomipramine hydrochloride or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber.
Common side effects include dry mouth, constipation, loss of appetite, sleepiness, weight gain, sexual dysfunction, and trouble urinating. Clomipramine was discovered in by the Swiss drug manufacturer Ciba-Geigy. In a meta-analysis of various trials involving fluoxetine Prozac, fluvoxamine Luvox, and sertraline Zoloft to test their relative efficacies in treating OCD, clomipramine was found to be the most effective. Contraindications include. Clomipramine use during pregnancy is associated with congenital heart defects in the newborn.
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Anafranil is a tricyclic antidepressant. It affects chemicals in the brain that may be unbalanced.
- Sexual disorders such as premature ejaculation, erectile dysfunction ED, and low libido reduce quality of life in patients with depression, anxiety, and other psychiatric illnesses.
- Long-term safety and effectiveness have been established for use of clomipramine in pediatric patients 10 to 17 years old for the treatment of obsessive compulsive disorder OCD.
- Lichtenthal, J.
- Clomipramine HCl is a tricyclic antidepressant FDA approved for veterinary use in dogs for the treatment of separation anxiety.
Nuit cu 10 mg pe zi? Lactation: Since the active substance passes into the breast milk, Anafranil should be gradually withdrawn or the infant weaned if the patient is breast-feeding.
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In children and adolescents, there is not sufficient evidence of safety and efficacy of clomipramine in the treatment of depressive states, phobias and cataplexy associated with narcolepsy. The use of clomipramine in children and adolescents years of age in these indications is therefore not recommended see section 4.
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Avoid; strong anticholinergic and sedative effects; may cause orthostatic hypotension Beers criteria. In children and young adults, risks must be weighed against the benefits of taking antidepressants. Patients should be monitored closely for changes in behavior, clinical worsening, and suicidal tendencies; this should be done during initial months of therapy and dosage adjustments. Worsening behavior and suicidal tendencies that are not part of the presenting symptoms may require discontinuation of therapy. Clinical worsening and suicide ideation may occur despite medication in adolescents and young adults yr. Potentially life-threatening serotonin syndrome reported when coadministered with drugs that impair serotonin metabolism in particular, MAOIs, including nonpsychiatric MAOIs, such as linezolid and IV methylene blue.
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