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Amitriptyline hydrochloride is given orally. Although amitriptyline has been administered in up to 4 divided doses throughout the day, it is long-acting and the entire oral daily dose may be administered at one time. Administration of the entire daily dose at bedtime may reduce daytime sedation. In patients who were unwilling or unable to take amitriptyline orally, the drug also has been given IM. Oral therapy should replace IM administration as soon as possible. There is a wide range of oral amitriptyline hydrochloride dosage requirements, and dosage must be carefully individualized. Patients should be monitored for possible worsening of depression, suicidality, or unusual changes in behavior, especially at the beginning of therapy or during periods of dosage adjustment.

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Although common in clinical settings, major depressive disorder with associated anxious symptoms 'anxious depression' has not been well studied in antidepressant clinical trials. The aim of this study was to compare the effects of fluoxetine versus amitriptyline in this group of patients. After a single-blind placebo run-in period of 2 weeks, patients were treated on a double-blind basis with fluoxetine or amitriptyline for 8 weeks. A total of patients were randomized to either fluoxetine or amitriptyline. Fluoxetine was comparable to amitriptyline in all efficacy measures except the HAMD sleep factor. Unwanted effects were more frequent and more severe in the amitriptyline-treated patients.

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Cialis is a latest medicine for treatment of disturbances of erection at men. Abstract Although common in clinical settings, major depressive disorder with associated anxious symptoms 'anxious depression' has not been well studied in antidepressant clinical trials.

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Adverse reactions to contrast agents can range from trivial skin rashes to life-threatening anaphylaxis. The commonest side effects are nausea and vomiting and hypersensitivity with intravenous use.

18.01.2021
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