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Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid GABA that was first approved for use in the United States in A governmentally-recognized ID which uniquely identifies the product within its regulatory market. In the United States, gabapentin is officially indicated for the treatment of postherpetic neuralgia in adults and for the adjunctive treatment of partial-onset seizures, with or without secondary generalization, in patients 3 years of age and older. It is also used in adults for the treatment of various types of peripheral neuropathic pain, such as painful diabetic neuropathy. Gabapentin is an anti-convulsant medication that inhibits the release of excitatory neurotransmitters, allowing for its use against pathologic neurotransmission such as that seen in neuropathic pain and seizure disorders.

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What about the newer anticonvulsants? Ryback et al. Fifteen of the adolescents were diagnosed with BD not otherwise specified, one with bipolar II and two with schizoaffective disorder, bipolar type. Two adolescents stopped taking gabapentin because of side effects. One adolescent experienced sedation, and the other developed rapid mood swings and irritability with methylphenidate Ritalin. Exceeding initial dose recommendations and concurrent administration of valproate acid increases the risk of rash.

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Prolactin elevation and consequent galactorrhoea is a known side effect of antipsychotics. Under normal circumstances, dopamine-producing neurons in the arcuate nucleus of the hypothalamus release dopamine in the hypothalamo-hypophysial blood vessels of the median eminence, which supply the pituitary gland. This dopamine inhibits prolactin secretion. When antipsychotics are taken, dopamine receptor blockade in the tuberoinfundibular pathway releases the lactotrope cells in the pituitary, which secrete prolactin, leading to consequent hyperprolactinemia. This in turn can cause side effects like galactorrhoea, breast enlargement, menstrual disturbances, amenorrhoea or sexual disturbances. Galactorrhoea is a troublesome and embarrassing side effect of antipsychotics.

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