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However, the final decision will always be the prescriber's.

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They can be caused by an exaggeration of a drugs intended pharmacological effect or by an unwanted action or side effect. Type A adverse reactions are most likely to occur buy flagyl online with paypal drugs that have a steep doseresponse curve andor small therapeutic ratio. The TR of a drug is the ratio of the maximum non-toxic dose to the minimum dose that has a therapeutic effect and is essentially a measure of a drugs safety margin. TR maximum non-toxic doseminimum effective dose The most dangerous drugs are those with a small TR where the maximum non-toxic dose is very close to the effective dose. Their use cannot be justified for trivial illnesses but they may be used for life-threatening conditions when the benefits outweigh the risks. Drugs with a TR of one or less cannot be used therapeutically.

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Many drugs can be actively secreted by this mechanism, which increases their rate of removal from the body. Active transport does not depend on concentration gradients and can overcome plasma protein binding. As the buy flagyl online with paypal drug is transported, more of the drug dissociates from the protein binding site and can be eliminated. Substances transported by the same transport system compete with each other and the more slowly a drug is transported the more effective it is at inhibiting the transport of another. A well-documented historical example of this is the competition between penicillin and probenecid.

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There are many antihistamines available and they differ in their duration of action, anticholinergic effects and incidence of drowsiness. Older antihistamines are the most likely to cause drowsiness.

  • In this way, trimethoprim interferes with the conversion of folate into its activated form, which is a cofactor in the synthesis of bacterial DNA.
  • Nhs.
  • This can allow minor surgery or other treatment of a body part.
  • This brings about the cellular response to the original hormone, for example growth.
  • However, in many cases of angina, the coronary arteries are partially occluded and blood flow through them does not increase significantly.
  • There are longer-term controls on blood pressure involving several hormones.
  • Treatment should be started as early as possible, when the first tingling sensation is felt.

If the enzyme is inhibited these substances cause rapid elevation in blood pressure leading to a hypertensive crisis, which can be fatal. Newer selective drugs inhibit MAO-A reversibly, allowing displacement by exogenous amines and so are less likely to interact with drugs and food substances and are safer.

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Erythromycin, an antibiotic, similarly increases the activity of theophylline, warfarin and digoxin. Response to drugs varies between individuals and although the reasons are often multifactorial there are cases where gene polymorphism is responsible.

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Diabetes mellitus is a chronic metabolic disorder caused by deficiency of insulin. Hyperglycaemia results because cells are unable to take up and use glucose. When the renal This glycosuria causes osmotic diuresis and polyuria. Loss of fluid causes dehydration and bought flagyl online with paypal thirst and polydipsia. Other metabolic disturbances are seen, including protein wasting and ketosis due to increased lipid breakdown. Long-term complications develop, many due to disease of blood vessels.

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Baroreceptors continually send impulses to the cardiovascular centre. If blood pressure rises, the rate of impulses being sent to the cardiovascular centre increases. In response to this, the cardiovascular centre reduces heart rate and force of contraction by decreasing sympathetic stimulation and increasing parasympathetic stimulation of the heart. At the same time sympathetic stimulation of blood vessels decreases. The overall effect is that cardiac output is reduced, blood vessels dilate and blood pressure returns to normal.


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It does this by inhibiting an enzyme, xanthine oxidase.

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Pharmacology is also the study of the toxic effects of drugs and chemicals in the environment. All drugs are capable of being toxic and all drugs can produce unwanted effects at high doses, or if used incorrectly.

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Bupivacaine can also be used with adrenaline. Bupivacaine is often used to produce continuous epidural anaesthesia during labour.

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