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Pioglitazone represents peroral hypoglycemic medicine of Thiazolidinediones alignment which effect depends on insulin presence.

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Common side effects include headaches, muscle pains, inflammation of the throat, and swelling. Pioglitazone was patented in, and came into medical use in It is ineffective and possibly harmful in diabetes mellitus type 1 and diabetic ketoacidosis. Pioglitazone and all other drugs of its class thiazolidinediones are absolutely contraindicated in patients with heart failure. The risk of hypoglycemia is low in the absence of other drugs that lower blood glucose. Pioglitazone can cause fluid retention and peripheral edema.

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