Bupropion hydrochloride is used in the treatment of major depressive disorder. Efficacy of conventional bupropion tablets for long-term use i. Efficacy of bupropion for the management of major depression has been established by a controlled study of approximately 6 weeks' duration in an outpatient setting and by 2 controlled studies of approximately 4 weeks' duration in inpatient settings. Patients received or mg daily of bupropion hydrochloride in the second study of 4 weeks' duration, which demonstrated efficacy only of the higher dosage, as indicated by improvement in total score on the HAM-D and in the CGI-S scale. However, in the study of 6 weeks' duration that evaluated the efficacy of mg daily of bupropion hydrochloride, the drug was superior to placebo in improvement of total score on the HAM-D, which was the primary measure of efficacy.

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Common side effects of bupropion include a dry mouth, difficulty sleeping, agitation, and headaches. Adjunctive therapies Atypical antipsychotics aripiprazole, brexpiprazole, lurasidone, olanzapine, quetiapine, risperidone Buspirone Lithium lithium carbonate, lithium citrate Thyroid hormones triiodothyronine T 3, levothyroxine T 4.

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First of all, antidepressant Wellbutrin bupropion treats major depressive disorder and seasonal affective disorder. In addition, it is used as a smoking cessation aid. Wellbutrin is one of the most prescribed antidepressants in the US and Canada. This medication is a norepinephrine-dopamine reuptake inhibitor, so it differs from such antidepressants as selective serotonin reuptake inhibitors that are also very popular. Bupropion was first made in, and was approved for medical use in

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