A current assessment of case reports of possible drug-induced pancreatitis is needed. Cases caused by multiple drugs or combination therapy were excluded. A classification system for associated drugs was developed a priori based upon the number of cases, re-challenge, exclusion of non-drug causes of acute pancreatitis, and consistency of latency. Seven-hundred and thirteen cases of potential drug-induced pancreatitis were identified, implicating unique drugs. Much of the case report evidence upon which drug-induced pancreatitis associations are based is tenuous. A greater emphasis on exclusion of all non-drug causes of acute pancreatitis and on quality reporting would improve the evidence base.

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