Christine I Chen, Heather J. Venner, Suzanne Lentzsch, Gary J. Blood ; Supplement 1 : Introduction - The nuclear export protein exportin 1 XPO1 is overexpressed in a wide variety of cancers including multiple myeloma MM. Selinexor forces nuclear retention and reactivation of cell cycle regulators such as p53, IkB, and Rb. The primary objectives were to determine the maximum tolerated dose MTD, recommended phase 2 dose RP2D, safety, and preliminary efficacy of the combination of selinexor, pomalidomide, and low dose dex SPd in pts with RRMM. The median age is 61 years and patients received a median of 4 range, 2 - 9 prior treatment regimens.

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Dexamethasone is a type of corticosteroid medication. The long-term use of dexamethasone may result in thrush, bone loss, cataracts, easy bruising, or muscle weakness. Dexamethasone was first made in and was approved for medical use in Dexamethasone is used to treat many inflammatory and autoimmune conditions, such as rheumatoid arthritis and bronchospasm. It is unclear whether dexamethasone in this condition is significantly better than other glucocorticoids. Dexamethasone is commonly given as a treatment for croup in children, as a single dose can reduce the swelling of the airway to improve breathing and reduce discomfort. It is injected into the heel when treating plantar fasciitis, sometimes in conjunction with triamcinolone acetonide. It is useful to counteract allergic anaphylactic shock, if given in high doses. It is present in certain eye drops — particularly after eye surgery — and as a nasal spray, and certain ear drops can be combined with an antibiotic and an antifungal.

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Initially, 0. Adjust according to patient response. Hydrocortisone and cortisone are preferred for these conditions; dexamethasone has no mineralocorticoid properties. Dosages required may be variable. Although most experts recommend hydrocortisone as first-line treatment of adrenal insufficiency in pediatric patients whose linear growth is incomplete due to a lower incidence of growth suppression, other authors have stated that dexamethasone may be used safely with close monitoring and individualization of dose based on growth, bone age, and hormone levels. NOTE: Hydrocortisone and cortisone are preferred for these conditions; dexamethasone has no mineralocorticoid properties.

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Study of the protective effect decadron 80 mg dexamethasone on cisplatin-induced ototoxicity in rats 1. Acquisition and interpretation of data, technical procedures, manuscript preparation. Acquisition of data, technical procedures. Analysis and interpretation of data, technical procedures, critical revision. To evaluate the ability of dexamethasone to protect against cisplatin CDDP -induced ototoxicity. It was found that dexamethasone did not protect against weight loss in CDDP-exposed animals.

By Matthew Stenger September 25, Advertisement. In the phase IIb STORM Part 2 study decadron 80 mg in The New England Journal of Medicine, Chari et al found that the combination of oral selinexor and dexamethasone produced responses in patients with multiple myeloma refractory to prior treatment with an alkylating agent, immunomodulatory agent, and daratumumab triple-class refractory. Patients were enrolled between May and March and treated with selinexor 80 mg and dexamethasone 20 mg twice weekly until disease progression or discontinuation. Patients had to have previous exposure to bortezomib, carfilzomib, lenalidomide, pomalidomide, daratumumab, and an alkylating agent. Median duration of response was 4.

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Pomalidomide 4 mg by mouth PO days of a 28 days cycle. Randomized Phase II - Pomalidomide high dose dexamethasone. Randomized Phase II - Pomalidomide high dose dexamethasone and oral cyclophosphamide. COVID is an emerging, rapidly evolving situation. Save this study.

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To evaluate the effect of 40 and 80 mg intravenous IV dexamethasone versus placebo to reduce postlumbar diskectomy pain. Unfortunately, some patients have radicular pain for several days after successful surgery, possibly caused by nerve root inflammation. A total of 61 patients with single-level herniated lumbar disc at L4-L5 or L5-S1 were randomly assigned to 3 groups. After the skin incision, group 1 received 40 mg, group 2 received 80 mg Decadron 80 mg dexamethasone, and group 3 received placebo. All patients also received 50 mg ranitidine IV at the same time. Preoperative and postoperative radicular and LBP were evaluated using the visual analog scale.

It's used to treat a variety of health conditions, including allergies, arthritis, problems with blood or bone marrow, skin problems, and flare-ups of multiple sclerosis MS. Dexamethasone is a corticosteroid, a class of steroid hormone. It's available to be taken orally or as an intravenous IV injection. Veterinarians prescribe dexamethasone for dogs and cats when they need to treat immune system problems such as asthma, hives, itching, inflammation, and skin and eye problems. Your doctor will not prescribe dexamethasone if you have a fungal infection anywhere in your body decadron 80 mg the medicine may worsen the infection. The medicine may affect the way the vaccine works.

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