This drug has also been the subject of much medical research, and many studies have been conducted, to explore other potential benefits. This research focused on whether or not it is suitable or effective at helping with weight loss, sexual dysfunction, Crohn's disease, psoriasis and other conditions. The active ingredient in this medicine has even been used to help people quit smoking. However, doctors generally only prescribe it for treating depression. Dosage and Administration Patients need to consult their doctor, for a thorough medical assessment, before treatment with Wellbutrin Bupropion Hydrochloride can begin. Patients who are treating seasonal affective disorder are sometimes told to start taking it in autumn, with treatment continuing through the winter. They may then have their dosage gradually reduced in early spring, after which treatment is stopped altogether.

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It has a unique pharmacology, inhibiting the reuptake of noradrenaline and dopamine, potentially providing pharmacological augmentation to more common antidepressants such as selective serotonergic reuptake inhibitors SSRIs. Bupropion is generally well tolerated, it has very low rates of sexual dysfunction, and is more likely to cause weight loss than gain. Major depressive disorders MDD are a leading global cause of morbidity. Escitalopram: Grossman et al. Idazoxan: Male: Continued with current medication including atypical antipsychotics, lithium, divalproex sodium.

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Cigarette smoking remains the largest preventable cause of premature death in developed countries. Bupropion, the first non-nicotine based drug for smoking cessation was licensed in the United States of America US in and in the United Kingdom UK in for smoking cessation in people aged 18 years and over. Bupropion exerts its effect primarily through the inhibition of dopamine reuptake into neuronal synaptic vesicles. It is also a weak noradrenalin reuptake inhibitor and has no effect on the serotonin system. Bupropion has proven efficacy for smoking cessation in a number of clinical trials, helping approximately one in five smokers to stop smoking. Up to a half of patients taking bupropion experience side effects, mainly insomnia and a dry mouth, which are closely linked to the nicotine withdrawal syndrome.

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