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Other more specialized treatments are cryotherapy, using liquid nitrogen, electrosurgery, surgical excision, bleomycin injections and carbon dioxide laser. Fungal infection of the skin and nails will be familiar to podiatrists.
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Dantrolene has a direct action on skeletal muscle to cause relaxation; baclofen inhibits transmission at the spinal cord by acting on inhibitory presynaptic gamma-aminobutyric acid B receptors; benzodiazepines cause muscle relaxation by some central action; and tizanidine is an α action. Side effects of dantrolene, baclofen and tizanidine are similar, being motor incoordination, drowsiness, dizziness, weakness, fatigue and gastrointestinal disturbances.
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