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Serotonin syndrome may occur, particularly during combined use with SSRIs eg, fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, escitalopram or SNRIs eg, venlafaxine, duloxetine ; discontinue therapy if it occurs.

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Serotonin-receptor 1B and 1D agonist triptan Used for acute treatment of migraine with or without aura and cluster headaches Potential for serious cardiac adverse effects. May repeat dose once with a minimum 1-hour interval between doses if migraine symptoms return. The maximum dose within 24 to 48 hours is 12 mg. If side effects are limiting, a lower dose may be used. The maximum cumulative daily dose is 12 mg. May repeat a dose 2 hours after the first dose if the headache has not resolved or returns after transient improvement.

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Migraine is a complex condition with a wide variety of symptoms. For many people, the main feature is a painful, and often disabling, headache. Other symptoms include disturbed vision; sensitivity to light, sound, and smells; feeling sick; and vomiting. Migraine affects about 1 person in 8, mainly women, and mainly in the age range of 30 to 50 years. Sumatriptan is one of the triptan family of drugs used to treat migraine attacks. It can be given by four different routes: by mouth oral, by injection under the skin subcutaneous, by nasal spray intranasal, and by suppositories rectal. The most commonly used doses of oral, rectal, and intranasal sumatriptan also provided useful pain relief. Subcutaneous sumatriptan was also the fastest acting, providing more people with pain relief within one hour of treatment than any other route of administration. Adverse events, which were mostly of mild or moderate severity and of short duration, were more common with subcutaneously administered sumatriptan and higher doses of oral and intranasal sumatriptan than with other dose and route combinations.

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You should not use sumatriptan if you have ever had heart disease, coronary artery disease, blood circulation problems, Wolff-Parkinson-White syndrome, uncontrolled high blood pressure, severe liver disease, a heart attack or stroke, or if your headache seems to be different from your usual migraine headaches. Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Do not use sumatriptan within 24 hours before or after using another migraine headache medicine. Sumatriptan is a headache medicine that narrows blood vessels around the brain. Sumatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms.

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Back to Medicines A to Z. Sumatriptan is a medicine to treat migraines and cluster headaches. It does not prevent these conditions. You take sumatriptan once a migraine or cluster headache has started. It is not a painkiller but you can use this medicine if painkillers or non-steroidal anti-inflammatory drugs NSAIDs have not worked.

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For coverage of additional quantities, a member's treating physician must request prior authorization through the Pharmacy Management Precertification Unit. See criteria under section III below. According to the manufactures, these anti-migraine agents are not intended for the prophylactic therapy of migraine or for use in the management of hemiplegic or basilar migraine. Safety and effectiveness of these agents have not been established for cluster headache, which is present in an older, predominantly male population. Ergot-containing drugs have been reported to cause prolonged vasospastic reactions.

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Subcutaneous injection of Sumatriptan is indicated for the acute relief of migraine attacks, with or without aura, and for the acute treatment of cluster headache. Sumatriptan Injection should only be used where there is a clear diagnosis of migraine or cluster headache. The efficacy of sumatriptan is independent of the duration of the attack when starting treatment. Administration during a migraine aura prior to other symptoms occurring may not prevent the development of a headache. It is recommended to start the treatment at the first sign of a migraine headache, cluster headache or associated symptoms such as nausea, vomiting or photophobia.

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Government of Newfoundland and Labrador. Strength This refers to the amount of the active medicinal ingredient e.

  • Common side effects include chest pressure, feeling tired, feeling of the world spinning, vomiting, tingling.
  • For greater effectiveness and faster relief, use this product at the first sign of a migraine.
  • One 5 or 10 mg tablet PO at onset of migraine headache; can be repeated in two hours.
  • Do not use this medicine for a migraine or cluster headache that is different from your usual headaches.
  • Imitrex Injection is indicated in adults for 1 the acute treatment of migraine, with or without aura, and 2 the acute treatment of cluster headache.
  • Reevaluate if no response.

Metrics details. A 6-mg dose of SC sumatriptan is the most efficacious and fast-acting acute treatment for migraine, but a 3-mg dose of SC sumatriptan may improve tolerability while maintaining efficacy.

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Each 0. The pH range of both solutions is approximately 4.

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It can make you feel tired or sleepy. If this happens, do not drive and do not use tools or machines. Your chest may feel tight or 'heavy' after taking sumatriptan. These sensations do not usually last for long, but if they continue or become intense, do not take any more sumatriptan and let your doctor know as soon as possible. Other side-effects may occur, but they are generally mild and do not last for long. In people with migraine, it is thought that some chemicals in the brain increase in activity and as a result parts of the brain then send out confused signals which result in the symptoms of headache and sickness.

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Sumatriptan is a serotonin receptor agonist commonly used to treat migraines and sometimes cluster headaches. A governmentally-recognized ID which uniquely identifies the product within its regulatory market. A combination sumatriptan and imitrex 6mg tablet is indicated for the treatment of migraines with or without auras in patients 12 years of age and older. Sumatriptan constricts cranial blood vessels and prevents the release of vasoactive peptides. Comprehensive structured data on known drug adverse effects with statistical prevalence.


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Examples are amlodipine and nifedipine. Nifedipine also has a use in the treatment of Raynauds disease.

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