These side effects vary between different types of progestins, making some more suitable for long term management than others. See also the article on Mirena.

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Medroxyprogesterone contraceptive injections and oral tablets are contraindicated in patients with pre-existing breast cancer. The oral tablets are contraindicated in any other known or suspected estrogen- or progestin-dependent neoplasia, including cervical cancer, endometrial cancer, uterine cancer, or vaginal cancer. Medroxyprogesterone depot injection suspension for the treatment of endometrial or renal cancer should generally not be used in women with a history of breast cancer, as breast cancer may be hormonally sensitive. Women with a strong family history of breast cancer should be monitored with particular care. Do not use medroxyprogesterone products in patients with undiagnosed abnormal genital or vaginal bleeding. The use of estrogen-alone and estrogen plus progestin has been reported to result in an increase in abnormal mammograms, requiring further evaluation. In the same WHI substudy, invasive breast cancers were larger, were more likely to be node positive, and were diagnosed at a more advanced stage in the combined HRT group compared with the placebo group. Metastatic disease was rare, with no apparent difference between the 2 groups. Other prognostic factors, such as histologic subtype, grade and hormone receptor status did not differ between the 2 groups. Observational studies also suggest that the risk of breast cancer was greater, and became apparent earlier, with combined HRT as compared to estrogen-alone therapy.

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It is very important that you use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects. The dose of this medicine will be different for different patients. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine.

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Women with benign heavy menstrual bleeding have the choice of a number of medical treatment options to reduce their blood loss and improve quality of life. Ulipristal acetate versus leuprolide acetate for uterine provera 5 mgs.

Medroxyprogesterone is used to treat conditions such as absent or irregular menstrual periods, or abnormal uterine bleeding. Medroxyprogesterone is also used to decrease the risk of endometrial hyperplasia a condition that may lead to uterine cancer while taking estrogens. Medroxyprogesterone is also used to prevent overgrowth in the lining of the uterus in postmenopausal women who are receiving estrogen hormone replacement therapy. Medroxyprogesterone should not provera 5 mgs used to prevent heart disease, stroke, or dementia. This medicine may actually increase your risk of developing these conditions.

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Active thrombophlebitis, or current or past history of thromboembolic disorders, or cerebral vascular disease. Use caution in patients with asthma, diabetes mellitus, history of depression, epilepsy, migraine, porphyria, systemic lupus erythematosus, and hepatic hemangiomas. If used with conjugated estrogens, may increase risk of MI, stroke, pulmonary emboli, DVT, breast cancer; discontinue therapy in patients who develop thrombosis. In some epidemiologic studies, use of estrogen plus progestin and estrogen-only products, in particular for 5 or more years, has been associated with increased risk of ovarian cancer; however, duration of exposure associated with increased risk is not consistent across all epidemiologic studies and some report no association. Studies of addition of progestin for 10 or more days of cycle of estrogen administration, or daily with estrogen in a continuous regimen, have reported lowered incidence of endometrial hyperplasia than would be induced by estrogen treatment alone; possible risks associated with the use of progestins with estrogens compared to estrogen-alone regimens include an increased risk of breast cancer. Most women using depo-subQ medroxyprogesterone experienced changes in menstrual bleeding patterns, such as amenorrhea, irregular unpredictable spotting or bleeding, prolonged spotting or bleeding, or heavy bleeding; in cases of unexpected abnormal vaginal bleeding, adequate diagnostic measures are indicated.

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Your dose of medroxyprogesterone will depend on what you are being treated for. Your doctor or pharmacist will tell you how many tablets to take and how often to take them. The cells in this tissue need oestrogen another female sex hormone to provera 5 mgs and survive. Medroxyprogesterone reduces the effect of oestrogen on these cells which causes them to 'shrink'. Medroxyprogesterone is also prescribed although at higher doses than in the conditions mentioned above to help treat some cancers, particularly endometrial cancer. Medroxyprogesterone is also available as an injection to prevent pregnancy, and as tablets in combination with an oestrogen for hormone replacement therapy HRT during the menopause.

Medroxyprogesterone acetate is a progestational agent that suppresses gonadotropin, thus causing anovulation and hypoestrogenemia. Serdar E. The effectiveness of progestin-only therapy is similar to that with continuous COCs. Carl P. Log on to ExpertConsult.

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