Relevant articles were abstracted by a trained physician researcher. Expert opinion without explicit critical appraisal or based on physiology or bench research.

It is also effective in treating anxiety and panic disorder. TRPs See here instead.

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Depression Lower dosages are recommended for elderly patients and adolescents. The safety and effectiveness of Imipramine Hydrochloride Tablets USP as temporary adjunctive therapy for nocturnal enuresis in children less than 6 years of age has not been established. Psychiatric: Confusional states especially in the elderly with hallucinations, disorientation, delusions; anxiety, restlessness, agitation; insomnia and nightmares; hypomania; exacerbation of psychosis. Neurological: Numbness, tingling, paresthesias of extremities; incoordination, ataxia, tremors; peripheral neuropathy; extrapyramidal symptoms; seizures, alterations in EEG patterns; tinnitus. Anticholinergic: Dry mouth, and, rarely, associated sublingual adenitis; blurred vision, disturbances of accommodation, mydriasis; constipation, paralytic ileus; urinary retention, delayed micturition, dilation of the urinary tract. Allergic: Skin rash, petechiae, urticaria, itching, photosensitization; edema general or of face and tongue ; drug fever; crosssensitivity with desipramine. Hematologic: Bone marrow depression including agranulocytosis; eosinophilia; purpura; thrombocytopenia.

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Imipramine is indicated for use in pediatric patients 6 years and older for the treatment of nocturnal enuresis and in adolescents for the treatment of major depressice disorder. There are limited data on the use of imipramine in children for other indications. The difference in absolute risk of suicidal thoughts and behaviors across different indications was highest in those with major depression. The need for tofranil 2 5 mg antidepressant in children, adolescents, or young adults for any use must be weighed against the risk of suicidality; it is unknown if this risk extends to long-term use. All patients should be monitored for symptom worsening or suicidality, especially at treatment initiation or after dose changes.

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Relevant articles were abstracted by a trained physician researcher. Co-ingestion of additional substances could require different referral and management recommendations depending on their combined toxicities. Recommendations are in chronological order of likely clinical use. The grade of recommendation is in parentheses. Ingestion of a TCA in combination with other drugs might warrant referral to an emergency department.

Thank you for visiting nature. Clinical studies demonstrate that the antidepressant efficacy of St John's wort Hypericum is comparable to that of tricyclic antidepressants such as imipramine. Onset of efficacy of these drugs occurs after several weeks of treatment. Therefore, we used in situ hybridization histochemistry to examine in rats the effects of short-term 2 weeks and long-term tofranil 2 5 mg weeks administration of imipramine, Hypericum extract, and hypericin an active constituent of St John's wort on the expression of genes that may be involved in the regulation of the hypothalamic-pituitary-adrenal HPA axis. However, imipramine appears to be more effective in blocking stress effects on the HPA axis than the plant extract. St John's wort Hypericum perforatum L, Hyperi- caceae is a plant that has been used as a medicinal herb since ancient times.

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This medication is used to treat depression. It is also used with other therapies for the treatment of nighttime bed-wetting enuresis in children. Imipramine can help your child control nighttime bed-wetting. It works tofranil 2 5 mg restoring the balance of certain natural substances neurotransmitters such as norepinephrine in the brain. For bed-wetting, this medication may work by blocking the effect of a certain natural substance acetylcholine on the bladder.

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TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, imipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, imipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as imipramine and amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine.

Avoid; strong anticholinergic and sedative effects; may cause orthostatic hypotension Beers criteria. In short-term studies, antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults This increase was not seen in patients aged over 24 years; a slight decrease in suicidal thinking was seen in adults aged over 65 years. In children and young adults, risks must be weighed against the benefits of taking antidepressants. Patients should be monitored closely for changes in behavior, clinical worsening, and suicidal tendencies; this should be done during the initial months of therapy and dosage adjustments. Worsening behavior and suicidal tendencies that are not part of the presenting symptoms may require discontinuation of therapy.

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