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Griseofulvin interacts with microtubules in fungal cells preventing the formation of the spindle during mitosis. It can be used topically and orally to treat skin and nail infections. Given orally the drug is sequestered into hair and nails. Recently the topical preparation has been added to the list of drugs that qualified, registered podiatrists can access and supply. Adverse effects of griseofulvin are gastrointestinal upset, headache and photosensitivity.
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