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Because propranolol is extensively metabolized affected individuals show exaggerated and prolonged responses to this drug. Another example is the metabolism of isoniazid, a drug used to treat tuberculosis. This drug is metabolized by acetylation and can lead to toxic effects.
There are serious side effects, such as gastrointestinal perforation and impaired wound healing, and its use is being monitored by the MHRA. Other areas of research include the development of drugs that block the capacity of oncogenes to turn cells malignant; antagonists of growth factors; inhibitors of cell cycle control factors; and gene therapy to restore tumour suppressor gene function. Cancer occurs when mutated cells divide uncontrollably, taking up space and spreading to distant parts of the body. Treatment is usually with a combination of surgery, irradiation and chemotherapy. The aim of chemotherapy is to interfere with cell division in tumour cells without damaging normal healthy cells.
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The proprietary name is the name given to a drug by the manufacturing company. As the same drug can be manufactured by several different companies, a drug can have multiple proprietary names and this can be confusing. Hence, proprietary names have been avoided in this book except where the proprietary name is in common usage. In the United Kingdom, the generic name is known as the British approved name. Following European Directive European Law requires the use of the recommended International Non-proprietary Name (rINN).
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Authored by Dr. Meredith L Oudt, DC
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It is a varied and complex system involving many glands and many hormones that work in balance via interconnected feedback control systems. Hormones are chemicals that are released into the blood stream where they travel to distant tissues and their sites of action.
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The adrenal glands are situated one above each kidney.
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