Desmopressin is a synthetic vasopressin analog with antidiuretic action that has been used in enuretic children since the late s. From: Handbook of Clinical Neurology, Martina C. Murphy MD, Harvey G. DDAVP may be self-administered by patients at home to prevent or treat bleeding episodes. Has other hemostatic effects on platelets and endothelium.

Initially, 0. The usual dosage range is 0. If patients are receiving intranasal therapy, begin oral therapy 12 hours after the last intranasal dose. During the initial titration period and continued therapy, observe and monitor closely. Adjust treatment according to the diurnal pattern of response. Response should be estimated by 2 parameters, adequate duration of sleep and adequate, not excessive, water turnover. In the elderly, careful fluid intake restrictions are required to prevent hyponatremia and water intoxication.

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DDAVP contains as active substance desmopressin acetate, a synthetic analogue of the natural hormone arginine vasopressin. It may be used alone or adjunctive to behavioral conditioning or other nonpharmacological intervention. The use of DDAVP Nasal Spray in patients with an established diagnosis will result in a reduction in urinary output with increase in urine osmolality and a decrease in plasma osmolality. For intranasal use only. DDAVP should be used with caution in patients with conditions associated with fluid and electrolyte imbalance, such as cystic fibrosis, because these patients are prone to hyponatremia.

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Desmopressin nasal may cause serious and possibly life-threatening hyponatremia low level of sodium in your blood. Symptoms of overdose may include: confusion drowsiness headache difficulty urinating sudden weight gain seizures.

Central cranial diabetes insipidus. Monitor fluid intake, urine volume and osmolality. Habitual or psychogenic polydipsia. Coronary artery insufficiency. Inj: Predisposition to thrombosis.

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Before application blow the nose. Place nozzle inside the nostril and press once. One actuation delivers a dose of 10 micrograms desmopressin acetate trihydrate. If higher doses are prescribed it is recommended that one-half of the dose be administered per nostril. While spraying breathe in slightly. The optimal dosage of Desmopressin Spray must be established individually and should be based on measurements of urine volume and osmolality.

Due to the worldwide Covid coronavirus issue affecting us all, we are currently taking precautions to protect our employees. To avoid any potential shipping delays that are out of our control, we highly recommend that customers place their orders an extra two weeks ahead of time. Prescription Required. Desmopressin is an antidiuretic, which reduces the amount of urine produced by the kidneys. Always use Desmopressin nasal spray exactly as your doctor has told you. If you are not sure, check with your doctor or pharmacist.

DDAVP contains as active substance desmopressin acetate, a synthetic analogue of the natural hormone arginine vasopressin. Disodium phosphate dihydrate.

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