Diclofenac sodium is a non-steroidal anti-inflammatory drug widely used as an opioid sparing agent for postoperative analgesia. Anaphylaxis due to intravenous diclofenac sodium is very rare. We report a case of anaphylactic reaction to IV diclofenac sodium, occurring postoperatively in a year-old primigravida, the clinical features of which mimicked pulmonary embolism. The rarity, clinical importance and the diagnostic dilemma associated prompted us to report this case. Diclofenac sodium is a non-steroidal anti-inflammatory drug NSAID widely used as an opioid sparing agent for postoperative analgesia.

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Diclofenac is a widely used nonsteroidal antiinflammatory drug NSAID that has been repeatedly demonstrated to cause acute hepatic injury and occasionally acute hepatic failure. Diclofenac is a preferential COX-2 inhibitor that has been extensively used for the treatment of acute and chronic inflammatory pain. Miles Hacker, in Pharmacology, Diclofenac is an NSAID widely used in the treatment of rheumatoid diseases such as osteoarthritis, rheumatoid arthritis, and alkylosing spondylitis. Obtaining exact numbers of patients developing this toxicity is very difficult as there is significant underreporting, a problem addressed earlier in the chapter. Further, drug-induced ROS have been reported to alter mitochondrial membrane function in other ways such as elimination of the inner transmembrane potential. Figure Liver metabolism of diclofenac. Although much has been learned regarding this toxicity much still remains unknown. We do not understand the role of the genetic makeup of the patient, the role of the environment regarding sensitivity of this toxicity, nor the actual mechanism of the toxicity.

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Diclofenac injection is a nonsteroidal anti-inflammatory drug NSAID used to treat adults with mild to moderate pain. It is used alone or given with other opioid narcotic pain medicines to treat adults with moderate to severe pain. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines.

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The molecular weight is The metabolites include 4'-hydroxy-, 5-hydroxy-, 3'-hydroxy-, 4',5-dihydroxy- and 3'-hydroxy-4'-methoxy diclofenac. For relief of signs and symptoms of osteoarthritis For relief of signs and symptoms of rheumatoid arthritis For acute or long-term use in the relief of signs and symptoms of ankylosing spondylitis. Voltaren should not be given to patients who have experienced asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Serious gastrointestinal toxicity such as inflammation, bleeding, ulceration, and perforation of the stomach, small intestine or large intestine, can occur at any time, with or without warning symptoms, in patients treated with nonsteroidal anti-inflammatory drugs NSAIDs.

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It is manufactured by Novartis Bangladesh Limited. Novartis Bangladesh Limited. Acute musculoskeletal disorders such as periarthritis e. Other painful conditions resulting from trauma, including fracture, low back pain, sprains, strains, dislocations, orthopaedic, dental and other minor surgery. It has potent voltaren 75 mg iv, analgesic and antipyretic actions.

The drug reduces the severity of acute pain an hour after its application. This is exactly how your parcel will look like pictures of a real shipping item. It has a size and a look of a regular private letter 9. Voltaren has analgesic, antipyretic, antiinflammatory effects, and is used to control the symptoms and signs of arthritic voltaren 75 mg iv. Voltaren is also used to control pain of varying severity, especially pain, caused by inflammatory processes.

Objective To examine the cardiovascular risks of diclofenac initiation compared with initiation of other traditional non-steroidal anti-inflammatory drugs, initiation of paracetamol, and no initiation. Design Series of nationwide cohort studies, each mimicking the strict design criteria of a clinical trial emulated trial design. Setting Danish, nationwide, voltaren 75 mg iv based health registries Participants Individuals eligible for inclusion were all adults without malignancy; schizophrenia; dementia; or cardiovascular, kidney, liver, or ulcer diseases that is, with low baseline risk. Main outcome measures Cox proportional hazards regression was used to compute the intention to treat hazard ratio as a measure of the incidence rate ratio of major adverse cardiovascular events within 30 days of initiation. The event rate for diclofenac initiators increased for each component of the combined endpoint 1.

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