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All prices are in US dollars. Olanzapine Zydis tablet has the advantage of faster onset of action over regular Olanzapine tablet. If Olanzapine side effects continue or are bothersome, check with your doctor. Ask your doctor or pharmacist if you have questions about which medicines cause dizziness. To prevent Olanzapine side effects like dizziness or fainting, sit up or stand slowly, especially in the morning.

Also, sit or lie down at the first sign of Olanzapine side effects like dizziness or weakness. It may also potentiate the effects of alcohol and CNS depressants such as sleeping tablets, antidepressants, and antianxiety medications. Use cautiously with these drugs and do not take with alcohol. The generic alternative is not manufactured by the company that makes the brand product.

Antidepressant Drugs. Asthma Medications. In an attempt to resolve the question of whether ODO has a more favorable weight gain profile than SOT, a rigorous double-blind double-dummy study was conducted by Karagianis et al. Moreover, the number of patients experiencing substantial weight gain ODO: However, a significant group difference in adherence was observed whereby ODO patients were more likely to take their medication as indicated, which may have impacted the incidence of weight gain in the ODO group due to greater and more prolonged antipsychotic exposure.

As pointed out by Karagianis et al, the analysis was not adjusted for these multiple secondary comparisons. In order to investigate the possible confounding effect that adherence may have had on the original results, Karagianis et al used data from the subset of adherent patients from the PLATYPUS study to investigate factors associated with weight gain during olanzapine treatment. Also, consistent with previous open-label findings, weight gain was lower in males but not females and patients residing in the US but not in Mexico or Canada treated with ODO, compared with those treated with SOT.

Given the posthoc and unpowered nature of these analyses, these exploratory results should be interpreted with caution. The currently available evidence regarding a difference in the potential for weight gain with ODO versus SOT is inconsistent and warrants further study. It should also be borne in mind that equivalence of weight gain during olanzapine treatment should not be an overriding consideration if it comes at the cost of lower adherence and potential relapse. Patient preference is an important factor in long-term treatment adherence and thus treatment outcomes.

Patients are more likely to persist with therapies they have had some active involvement in choosing, possibly aided by an enhanced therapeutic alliance as a consequence of improved patient motivation and insight into their illness and its treatment. One single-arm study provided data on patient acceptance. Medication nonadherence is an issue of significant clinical importance in patients with serious mental illnesses such as schizophrenia and bipolar disorder.

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