Lamotrigine may cause rashes, including serious rashes that may need to be treated in a hospital or cause permanent disability or death. Tell your doctor if you are taking valproic acid Depakene or divalproex Depakote because taking these medications with lamotrigine may increase your risk of developing a serious rash. Also tell your doctor if you have ever developed a rash after taking lamotrigine or any other medication for epilepsy or if you are allergic to any medications for epilepsy. Your doctor will start you on low dose of lamotrigine and gradually increase your dose, not more than once every 1 to 2 weeks. You may be more likely to develop a serious rash if you take a higher starting dose or increase your dose faster than your doctor tells you that you should.

Early reports suggested that women with bipolar disorder may be at lower risk for onset or relapse of this disorder during pregnancy and that some women may be able to remain well during pregnancy despite medication discontinuation. However, more recent studies have suggested that recurrence of affective illness during pregnancy is relatively common among women with bipolar disorder. Maintenance treatment with a mood stabilizer during pregnancy can significantly reduce the risk of relapse; however, many of the medications commonly used in this setting, including lithium and valproic acid, carry some degree of teratogenic risk. While other anticonvulsants are being used with increasing regularity for the treatment of bipolar disorder i. In a comparison group of, unexposed births, the prevalence rate for oral clefts was 0. However, other registries have not demonstrated such a significant increase in risk for oral clefts. Among a total of 1, lamotrigine-exposed infants surveyed in five other anticonvulsant registries, four infants with oral clefts were identified, indicating a frequency of or 2.

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Lamotrigine may cause a severe or life-threatening skin rash, especially in children and in people who take too high of a starting a dose, or those who also take valproic acid Depakene or divalproex Depakote. Lamotrigine is used either alone or in combination with other medications to treat epileptic seizures in adults and children. Lamotrigine may cause a severe or life-threatening skin rash, especially in children and in people who take too high a dose at the start of treatment. Serious skin rash may also be more likely to occur if you are taking lamotrigine together with valproic acid Depakene or divalproex Depakote. Some people have thoughts about suicide while taking this medicine. This is to track the outcome of the pregnancy and to evaluate any effects of lamotrigine on the baby.

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Tablets must be swallowed whole and must not be chewed, crushed, or divided. However, cases have occurred in the absence of lamictal xr 150mg factors. It is recommended that LAMICTAL XR not be restarted in patients who discontinued due to rash associated with prior treatment with lamotrigine unless the potential benefits clearly outweigh the risks. The greater the interval of time since the previous dose, the greater consideration should be given to restarting with the initial dosing recommendations. The half-life of lamotrigine is affected by other concomitant medications see Clinical Pharmacology

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Take this medicine only as directed by your doctor to help your condition as much as possible and to decrease the chance of unwanted effects. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Ask your doctor if you have any questions. Lamotrigine may be taken with or without food or on a full or empty stomach. However, if your doctor tells you to take the medicine a certain way, take it exactly as directed. If you are taking the chewable dispersible tablets, they may be swallowed whole, chewed, and swallowed, or dispersed in a small amount of liquid and swallowed.

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Lamotrigine use is contraindicated in patients who have demonstrated hypersensitivity to lamotrigine e. Due to the potential for life-threatening serious rash including Stevens-Johnson syndrome and toxic epidermal necrolysis, discontinue lamotrigine if rash occurs at any time during treatment. It is important to note that discontinuation of lamotrigine may not prevent progression to a higher level lamictal xr 150mg severity; therefore, monitor patients closely. Age is the only factor currently known to predict the occurrence or severity of a rash, with pediatric patients at increased risk. Other possible but unproven factors include concurrent use of valproate, exceeding the initial recommended dose, or exceeding the recommended dose titration.

Lamictal lamotrigine is used as a mood stabilizer for people with bipolar disorder and as an anticonvulsant for people with epilepsy. When used for bipolar disorder, Lamictal is prescribed as a maintenance drug to control mood swings after acute symptoms have been treated and are in remission. Lamictal XR is only used for the treatment of epilepsy, not bipolar disorder. Similarly, Lamictal CD is meant for children with epilepsy who can take the drug from the age of two. Your Lamictal dose may need to be adjusted if you become pregnant. Lamictal can cause side effects, many of which are transient and will resolve once your body adapts to the medication.

Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration FDA approval for the maintenance treatment of bipolar type I. It is approved for use in more than 30 countries. Lamotrigine has relatively few side-effects and does not require laboratory monitoring. While it is indicated for epilepsy and bipolar disorders, there is evidence that lamotrigine could have some clinical efficacy in certain neuropathic pain states.

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