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These drugs are recommended for use in women over history of fractures. Hormone replacement therapy with oestrogen and progesterone is no longer recommended and should not be used as first line treatment in post-menopausal women for osteoporosis. This is because of the increased risk of breast, endometrial and ovarian cancer with HRT. Its use should be reserved for patients in whom other drugs are contraindicated, not tolerated or ineffective. HRT is most effective if started early in the menopause and continued for up to five years (after which osteoporosis will return, possibly at an accelerated rate).

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Alternative approaches have been considered using genetically modified cells, for example fibroblasts from the skin, or retinal cells as sources of dopamine production. These approaches are still very much in the experimental stages. Epilepsy affects approximately The main symptoms are seizures, often together with convulsions, but there are many types of epilepsy.

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The main disadvantage of this route of administration is that most drugs do not taste nice. Nasal administration is often intended to have a local effect, as in the use of nasal decongestants, although certain drugs are given this way to have a systemic effect. For example, antidiuretic hormone used to treat diabetes insipidus and hormones used for infertility treatment can be given by this route. This route can be another way of avoiding destruction of a drug by liver enzymes or stomach acid and digestive enzymes.

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