Richard Knox. Wikimedia Commons hide caption. The painkiller diclofenac isn't very popular in the U. But evidence of the drug's cardiovascular risk hasn't translated to a reduction in use, a paper in the journal PLOS Medicine found. Henry tells Shots that diclofenac raises the risk of a cardiovascular event such as heart attack by about 40 percent, compared to taking no NSAID. And therefore, there's no advocacy lobby group on their behalf. The bad cardiovascular risk profile of diclofenac is no secret.

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What is diclofenac, and how does it work mechanism of action? Other members of this class include ibuprofen Motrin, indomethacin Indocin, nabumetone Relafen, naproxen Aleve and several others. NSAIDs work by reducing the production of prostaglandins, chemicals that cause pain, fever and inflammation. NSAIDs block the enzyme that makes prostaglandins cyclooxygenase, resulting in lower production of prostaglandins. As a consequence, inflammation, pain and fever are reduced. The FDA approved diclofenac in July What are the uses for diclofenac?

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What makes this gel so special is that it both relieves pain and inflammation. Voltaren Emulgel has a cooling, moisturising effect with no strong odours. Apply three or four times each day. Use for up to two weeks, if needed. If you have any other health conditions or you are taking any other medications, including those that do not require a prescription, always ask your pharmacist or doctor if Voltaren Emulgel is suitable for you.

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It works by reducing pain, swelling, and inflammation. It is generally used in addition to other non-medication measures such as getting enough rest to relieve these discomforts. If you have not discussed this with your doctor or are not sure why you are being given this medication, speak to your doctor. Do not stop using this medication without consulting your doctor. Do not give this medication to anyone else, even if they have the same symptoms as you do.

Indicated for management of mild-to-moderate pain and moderate-to-severe pain alone or in combination with opioid analgesics. To reduce the risk of renal adverse reactions, patients must be well hydrated prior to IV administration. Safety and efficacy not established; drug has been used safely in limited number of children aged years with juvenile rheumatoid arthritis. Absolute: Hypersensitivity to diclofenac, history of aspirin triad, treatment of perioperative pain associated with CABG; active gastrointestinal bleeding. IV: Moderate-to severe renal insufficiency in the perioperative period and patients who are at risk for volume depletion. Zipsor capsules are contraindicated in patients with history of hypersensitivity to bovine protein.

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Adults and children 14 years and over : The gel should be rubbed gently into the skin. The maximum daily dose is 8g. Therefore the maximum weekly dose is 56g. Children and adolescents: There are insufficient data on efficacy and safety available for the children and adolescents below 14 years of age see also contraindications section 4. Patients with or without chronic asthma in whom attacks of asthma, urticaria or acute rhinitis are precipitated by aspirin or other non-steroidal anti-inflammatory agents. Hypersensitivity to diclofenac, acetylsalicylic acid or other non-steroidal anti-inflammatory drugs.

It combines a gel and cream in one, which gives both a cooling and soothing effect when applied to the skin. Use an amount the size of a one penny or two penny piece 2 times daily preferably morning and evening to the affected area of skin. Do not use if you are allergic to Diclofenac or aspirin or other NSAIDs, or have ever had an allergic reaction to these ingredients, or you have ever had an asthma attack, wheezing, hives, or runny nose after taking these ingredients. Consult your doctor or pharmacist before using if you have a stomach or duodenal ulcer, or are pregnant or breastfeeding. Do not apply to cuts, wounds, sunburnt skin or other area where the skin is abnormal, or near the eyes or nose.

In addition, the Emulgel technology is a unique combination of a gel and cream providing both a cooling and soothing effect when applied to the skin. Gently rub or massage in a small amount of gel into the skin around painful or swollen area. An amount ranging in size from 1 penny to a 2 pence piece will usually be sufficient. However, the amount of gel needed will vary depending upon the size of the painful or swollen area maximum daily dosage 8g. Apply 2 times daily preferably morning and evening unless your doctor or pharmacist tells you otherwise.

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