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Pain is an unpleasant sensation designed to warn the body of potential damage and can have many different causes. Thankfully, most pain is caused by minor conditions and can be treated easily, quickly and effectively. The most common types of pain we help our patients with include headache, muscular pain, dental and period pain. A relatively minor headache will respond well to fluids and painkillers which should have some effect with 30 minutes or so. Some of the ways you can help relieve a headache include;. Back pain, aching limbs or a stiff neck can often be caused by a strained or pulled muscle during exercise, sleep or everyday life.

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Depot preparations are designed to give a slow sustained release of drug. Drugs injected intravenously go directly into the blood stream and are rapidly distributed around the body. An advantage of intravenous injection is that it is possible to get high concentrations of a drug very quickly to its site of action, although this may also lead to toxic effects in other tissues. Disadvantages of intravenous injection are that it requires trained personnel using sterile techniques and once 250 mg of fluoxetine drug has been given, mistakes cannot be rectified. Drugs can be given by continuous intravenous infusion, for example in cancer chemotherapy.

Apart from their local anaesthetic action, local anaesthetics have anticholinergic activity. This is 250 mg of fluoxetine partly to prevention of acetylcholine release and partly to non-depolarizing competitive block of the acetylcholine receptors on the postsynaptic membrane. The importance of this clinically is that local anaesthetics should be used with great care in patients suffering from myasthenia gravis because of the danger exacerbating the condition and precipitating paralysis, particularly of the respiratory muscles. Such patients should be treated as high risk. Cardiac muscle cells are excitable, and hence the diffusion of sodium ions is affected as it is in nervous tissue.

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