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The connection between antidepressants and violence and suicidality has been a subject of a great deal of debate in the research literature. These results and others have often been criticized or dismissed by those who point out that anxiety and suicidality are often symptoms associated with the conditions being treated. The drugs tested in these trials were citalopram, escitalopram, fluoxetine, paroxetine, and sertraline or venlafaxine. Only four of the final eleven trials were free of industry funding and industry authors.
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Psychopathology Journals | Insight Medical Publishing
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Replacement therapy is by intravenous or subcutaneous injection of epoetin. Increased destruction of erythrocytes, or haemolytic anaemia, occurs if erythrocytes are broken down prematurely and can be due to haemoglobin defects, abnormal enzymes, membrane defects, poisons or infections, incompatible blood, autoimmune disease or hereditary disease. Sickle cell disease and thalassaemia are examples of inherited haemolytic anaemias. Sickle cell disease is caused by a gene that codes for an abnormal kind of haemoglobin. In low oxygen tension, this type of haemoglobin crystallizes and becomes rigid. As a result, the erythrocytes become distorted and easily ruptured.
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Local anaesthetics can pass into the central nervous system through the blood brain barrier. They have the same effect on central nervous tissue as they have on peripheral nervous tissue; that is, they inhibit conduction of nerve impulses.
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Folic acid is converted into folate, which then has to be converted into an activated form by dihydrofolate reductase.
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The mouth is where food is chewed and mixed with saliva before being swallowed.
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If this is tolerated, higher concentrations can be used to provide optimum response.
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