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We aimed to compare indicators of Parkinson disease PD progression between patients first prescribed either selegiline or rasagiline as their antiparkinsonian drugs APDs on the basis of real-life data. Pharmacy data on members of a large Israeli health maintenance organization, treated as patients with PD during — and prescribed selegiline or rasagiline as their first APD, were analyzed. The first APD was selegiline for patients — and rasagiline for patients — Time from monoamine oxidase type B inhibitor prescription until initiating treatment with dopamine agonists DAs or levodopa was compared between the groups using Cox regression adjusted to sex and age at initiation of APD. The selegiline group was significantly older at first monoamine oxidase type B inhibitor purchase. The time to initiation of DA treatment was longer in the selegiline group adjusted HR, 1. The similarity in time to levodopa in both groups suggests no differences between selegiline and rasagiline in their effect on the natural history of PD. A possible interaction effect between rasagiline and DA might exist. A better symptomatic profile of selegiline more than that of rasagiline in the earlier stages of PD may explain the difference between the 2 groups in time to DA initiation. Medical treatment of Parkinson disease PD is symptomatic.

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Selegiline is used to treat canine cognitive dysfunction and a type of Cushing's disease caused by a pituitary tumor. DO NOT use with purchases selegiline. The starting dose for canine cognitive dysfunction is 0. It may take up to one month or more to see improvement. The usual starting dose to treat Cushings disease is 0. If no result within two months, may increase to 0.

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