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  • Adverse reactions to iodine contrast agents are related to iodine concentration, osmolality, whether the agent is ionized or not, the rate and frequency of injection and the dose given and the chemical composition of the agent.
  • The only preparation is a complex one combined with salicylic acid, available over the counter as Phytex.
  • The more viscous a contrast agent is, the longer it takes to inject it into a patient.
  • Unlike NSAIDs and corticosteroids, they do not produce an immediate therapeutic effect but require four to six months of treatment for a full response.

They are effective in the late phase reaction and reduce the intensity of allergic reactions. They are used in emergency treatment of severe acute attacks, for the treatment of mild to moderate attacks and prophylactically to prevent attacks.

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Cytarabine is used to treat leukaemia. Adverse effects of cytarabine are bone marrow suppression and gastrointestinal disturbances. Some cytotoxic antibiotics prevent cell division by direct action on DNA. Others form polynucleotides, which inhibit transcription of DNA to RNA and therefore suppress protein synthesis. Examples of cytotoxic antibiotics are doxorubicin, dactinomycin and bleomycin. Doxorubicin inhibits an enzyme called topoisomerase.


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The most common side effect is transient drowsiness. Allergy can occur in susceptible individuals.

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