Your medication may look different. If you have questions, ask your pharmacist. Armodafinil reduces extreme sleepiness due to narcolepsy and other sleep disorders, such as periods of stopped breathing during sleep obstructive sleep apnea. This medication does not cure these sleep disorders and may not get rid of all your sleepiness. If you have any questions, ask your doctor or pharmacist. For narcolepsy and obstructive sleep apnea, take this medication by mouth as directed by your doctor, usually once daily in the morning. If you are using armodafinil for shift work sleep disorder, take it as directed by your doctor, usually once a day 1 hour before you start your work shift.

Armodafinil is the R-enantiomer of modafinil which is a mixture of the R- and S-enantiomers. The chemical structure is Armodafinil is a white to off-white, crystalline powder that is slightly soluble in water, sparingly soluble in acetone, and soluble in methanol. Consideration should be given to the use of lower doses and close monitoring in geriatric patients see Use in Specific Populations. North Wales, PA

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Armodafinil tablets are indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea OSA, narcolepsy, or shift work disorder SWD. In OSA, armodafinil tablets are indicated to treat excessive sleepiness and not as treatment for the underlying obstruction. If continuous positive airway pressure CPAP is the treatment of choice for a patient, a maximal effort to treat with CPAP for an adequate period of time should be made prior to initiating armodafinil tablets for excessive sleepiness. The recommended dosage of armodafinil tablets for patients with OSA or narcolepsy is mg to mg taken orally once a day as a single dose in the morning. The recommended dosage of armodafinil tablets for patients with SWD is mg taken orally once a day as a single dose approximately 1 hour prior to the start of their work shift. In patients with severe hepatic impairment, the dosage of armodafinil tablets should be reduced see Use in Specific Populations 8. Consideration should be given to the use of lower doses and close monitoring in geriatric patients see Use in Specific Populations 8. Armodafinil Tablets are available containing 50 mg, mg or mg of armodafinil. Armodafinil tablets are contraindicated in patients with known hypersensitivity to modafinil or armodafinil or their inactive ingredients see Warnings and Precautions 5. Armodafinil tablets have not been studied in pediatric patients in any setting and are not approved for use in pediatric patients for any indication.

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In obstructive sleep apnea, indicated to treat excessive sleepiness and not as treatment for the underlying obstruction. Not recommended in patients with angina, cardiac ischemia, recent history of myocardial infarction, left ventricular hypertrophy, or mitral valve prolapse. History of depression, psychosis, mania; consider discontinuing armodafinil if psychiatric symptoms develop. May reduce effectiveness of steroidal contraceptives 1 month after discontinuation of drug therapy. Effectiveness of hormonal contraceptives may be reduced up to for one month after discontinuation of therapy; advise women who using a hormonal method of contraception to use additional barrier method or alternative non-hormonal method of contraception during treatment and for one month after discontinuation of treatment. Unknown; not sympathomimetic R-enantiomer of modafinil ; may increase dopamine levels in the brain by binding to the dopamine transporter and inhibiting dopamine reuptake.

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In geriatric adults, use lowest effective dose due to the possibility of adverse effects from decreased drug elimination. In obstructive sleep apnea, armodafinil is indicated to improve wakefulness in patients with excessive sleepiness and not as treatment for the underlying obstruction. If continuous positive airway pressure CPAP is the treatment of choice, a maximal effort to treat with CPAP for an adequate period of time should be made prior to initiating armodafinil for excessive sleepiness. The safety of armodafinil in patients with severe renal impairment is unknown. The clinical significance is unknown. The presence of food will delay maximum peak concentrations by approximately 2—4 hours; however, effects on overall bioavailability are minimal.

Armodafinil is produced by the pharmaceutical company Cephalon Inc. Because armodafinil has a longer half-life than modafinil does, it may be more effective at improving wakefulness in patients with excessive daytime sleepiness. Armodafinil is currently FDA-approved to treat excessive daytime sleepiness associated with obstructive sleep apnea, narcolepsy, and shift work disorder. In June, it was revealed that a phase II study of armodafinil as an adjunctive therapy in adults with schizophrenia had failed to meet the primary endpoints, and the clinical program was subsequently terminated. In placebo-controlled studies, the most commonly observed side effects were headache, xerostomia dry mouth, nausea, dizziness, and insomnia.

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Armodafinil is the active R-enantiomer of modafinil and is approved by the Food and Drug Administration for the treatment of EDS in narcolepsy. Armodafinil Nuvigil; Cephalon, Inc. The precise mechanisms of action through which armodafinil or modafinil promote wakefulness are unknown. Armodafinil and modafinil are effective in improving wakefulness, indicating their potential suitability as treatment for excessive sleepiness but not necessarily for CRSD. Christian Guilleminault, Michelle T. Armodafinil is the R -enantiomer of the racemic modafinil.

Nuvigil is used to treat excessive sleepiness caused by sleep apnea, narcolepsy, or shift work sleep disorder. You should not use Nuvigil if you have ever had a rash or allergic reaction caused by armodafinil or modafinil Provigil. Other signs of a severe reaction include fever, swelling in your face or tongue, mouth sores, trouble breathing, swelling in your legs, yellowing of your skin or eyes, and skin rash or blistering sores. Before using Nuvigil, tell your doctor if you have liver or kidney disease, heart disease or armodafinil 50 mg tablet blood pressure, a heart valve disorder, a history of mental illness, a history of drug or alcohol addiction, or if you have recently had a heart attack. It is not known whether Nuvigil will harm an unborn baby. Hormonal contraception birth control pills, injections, implants, skin patches, and vaginal rings will not effectively prevent pregnancy while you are taking Nuvigil.

Armodafinil is used to treat excessive sleepiness caused by narcolepsy a condition that causes excessive daytime sleepiness or shift work sleep disorder sleepiness during scheduled waking hours and difficulty falling asleep or staying asleep during scheduled sleeping hours in people who work at night or on rotating shifts. It works by changing the amounts of certain natural substances in the area of the brain that controls sleep and wakefulness. Armodafinil comes as a tablet to take by mouth. It is usually taken once a day. If you are taking armodafinil to treat narcolepsy or OSAHS, you will probably take it in the morning.

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