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Treatment of gout aims to control acute attacks with analgesics and colchicine and in the longer term to reduce circulating uric acid levels either by inhibiting its production with allopurinol or by encouraging its excretion by the kidneys with probenecid or sulfinpyrazone. Osteoarthritis is primarily a degenerative joint disease, but as joint destruction occurs this creates local inflammation. Treatment of osteoarthritis is with NSAIDs. Pagets disease and osteoporosis are conditions where there is loss of normal bone tissue due to overactivity of osteoclasts.
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The posterior pituitary gland secretes two hormones, antidiuretic hormone and oxytocin. They are both synthesized in the hypothalamus and reach the posterior pituitary via a neural connection.
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In general, a PGD is not meant to be a long-term means of managing a patients clinical condition.
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Corticosteroids suppress all phases of the inflammatory response, including the early swelling, redness and pain and the later stages seen in chronic inflammation.
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This is a relatively new group of drugs and adverse effects appear to be rare.
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