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The Prescription Only Medicines Order non-injection drugs to the patient for which they are intended and in the manner prescribed. Normally, drugs for injection can only be administered by the patient or by a medical practitioner. However, in an emergency, when used for the purposes of saving life, certain drugs may be administered parenterally by anyone.

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This results in a delay in electrical conduction in cardiac muscle, reduced contractility and reduction in the heart rate. Because of these effects, class I calcium channel blockers are used to treat ischaemic heart disease and atrial arrhythmia. An example is verapamil. Adverse effects are bradycardia, heart block and possible precipitation of heart failure. Class I calcium channel blockers are contraindicated in patients who already have these conditions.

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