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- Cyclophosphamide is metabolized to a toxic metabolite called acrolein, which can cause haemorrhagic cystitis, a rare but serious complication.
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This has two important effects on drug molecules: kidneys; This is not always the case. A drug metabolite may have a new and completely different pharmacological activity, or it may be as active as or more active than the original drug.
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Schizophrenia appears to have a genetic basis. The risk for the disease is greater in relatives of schizophrenics than that in the general population. The concordance rate for monozygotic twins is complex and likely to be an interaction between several genes and environmental factors. In schizophrenia, there appears to be overactivity of dopamine systems in areas of the brain associated with complex mental and emotional functions. This is the dopamine hypothesis of schizophrenia. There are four main neuronal systems in the brain in which dopamine is a transmitter: the basal nuclei; the hypothalamic-pituitary pathway and the mesolimbic and mesocortical pathways.
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An outline curriculum has been developed and agreed with the HPC who also accredits programmes provided by Higher Education Institutions. The pharmacology content of the training courses will include general principles of pharmacology: absorption, distribution, metabolism and excretion; individual variation to drug therapy, adverse drug reactions, drugdrug interactions, interactions with other diseases and drug interaction with receptors and the legal basis for prescribing, supply and administration of medicines, including regulatory aspects of controlled drugs.
15.12.2018
Simone
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Tubular secretion of drugs occurs in the proximal convoluted tubule by active transport mechanisms normally used for the removal of waste products.
25.03.2016
Katharina
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The ECG is a record of the sum of all action potentials in the heart as it contracts.
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Tim
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However, drugs can also affect channel function by binding directly to parts of the channel protein.
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Winfried
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This was to be funded from existing prescribing budgets and, as such, should be substitute prescribing not additional, as still applies today. Legislation was passed in Act, permitting nurses to prescribe.
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Artur
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