A traditional example of a lubricant laxative is liquid paraffin. Lubricants do not work fast enough to be useful prior to radiological imaging. Osmotic laxatives are salts that act osmotically by retaining the water they are given with, or by drawing water into the bowel from the body. This accelerates transfer of gut contents through the small intestine with an abnormally large volume entering the colon. This causes distension and reflex peristalsis.

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Adjuncts to radiography include peripherally acting analgesics and possibly codeine for pain after injection or other procedures and topical anaesthetics prior to injection. For abdominal examinations using barium contrast agents, laxatives and bowel evacuants are necessary to empty the bowel. The most commonly used preparation for this purpose is Picolax, which is a combination of a stimulant laxative and an osmotic laxative. Buscopan or glucagon is used to inhibit gastrointestinal activity while imaging is taking place.

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