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Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic. Some off-label indications of lorazepam include rapid tranquilization of an agitated patient, alcohol withdrawal delirium, alcohol withdrawal syndrome, muscle spasms, insomnia, panic disorder, delirium, chemotherapy-associated anticipatory nausea and vomiting, and psychogenic catatonia. The effect of lorazepam in GABA-A receptors produces an increase in the frequency of opening of the chloride ion channel. However, for its effect to generate, the neurotransmitter is required. This binding will result in an increase on the GABA inhibitory effects which is translated as an increase in the flow of chloride ions into the cell causing hyperpolarization and stabilization of the cellular plasma membrane. When administered orally, the time to attained maximum concentration is observed to be of 2 hours. An overdose stage can result in profound sedation, deep respiratory depression, coma, and death.
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