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Methotrexate inhibits an enzyme (dihydrofolate reductase) necessary for the synthesis of purine nucleotides (adenine and guanine), which are components of DNA. This results in a reduction in DNA synthesis and particularly affects rapidly dividing cells. Methotrexate is prescribed for oral administration once a week and it is extremely important the patients understand this. Bone marrow depression and hepatotoxicity are the main complications.

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Please select the extra items you wish to be included with your booking using the controls you see below. The 5 qm kitchen is fully equipped. There are 4 bedrooms in total. Smoking is allowed on the balcony. Bed sheets and towels available. The apartment should be left in the same condition as it was found. No deposit is required and the rent has to be paid on arrival and key collection. A copy of your passport is required. The usual initial adult oral dose of furosemide for the management of edema is mg given as a single dose, preferably in the morning.

In adults who do not respond, the second and each succeeding oral dose may be increased in to mg increments every hours until the desired diuretic response including weight loss is obtained. The effective dose may be given once or twice daily thereafter, or, in some cases, by intermittent administration on consecutive days each week. For maintenance, dosage may be reduced in some patients.

Adult oral dosage of furosemide may be carefully titrated up to mg daily in severely edematous patients. For maintenance, the minimum effective dosage should be employed. As a diuretic, the usual adult IM or IV dose is mg given as a single injection. The effective single dose may then be given once or twice daily. For the management of acute pulmonary edema in adults, 40 mg of furosemide may be slowly injected IV over minutes.

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