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In order to do this, the drug will have to cross several cell membranes to reach the blood (unless it is injected intravenously). The three ways by which substances, including drugs, can cross cell membranes are simple diffusion, facilitated diffusion and active transport.
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Heparin works by enhancing the formation of a complex of thrombin and antithrombin III. This effectively prevents thrombin from activating fibrinogen.
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Other known toxic causes include Wilsons disease, where there is deposition of copper in the basal nuclei, and mercury and manganese poisoning. Environmental factors that may play a role in the aetiology of Parkinsons disease include: living in a rural environment; using well water; exposure to pesticides; a diet high in animal fats or carbohydrates; or low consumption of foods rich in antioxidants such as vitamin C and E.
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Corticosteroids are anti-inflammatory drugs that can be used in asthma to reduce airway hyper-responsiveness and to decrease bronchial oedema and mucus secretion.
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