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This is because of their adverse effects in raising blood glucose levels. The antihypertensive effect of β-blockers is not completely understood. A decrease in heart rate and force of contraction would reduce cardiac output, but this is likely to be compensated for by the baroreceptor reflex. It is possible that β-blockers work, at least partially, by some central action in the cardiovascular control centres of the brain. β-blockers also block receptors in the peripheral blood vessels, kidney and bronchi.

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They also reduce the number of some receptors, which may contribute to the therapeutic action, but their complete mechanism of action is unknown. Examples of tricyclic antidepressants include imipramine and amitriptyline (for use of amitriptyline in neuropathic pain. The main side effects of tricyclic antidepressants are sedation, anti-cholinergic effects (dry mouth, constipation and urinary retention) and postural hypotension. Some patients may experience mania, seizures or impotence. Tricyclic antidepressants should be used with caution in patients with liver disease. Maprotiline is similar in structure to the tricyclics.

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Intravenous anaesthetics are used to induce general anaesthesia, followed by an inhalation anaesthetic for maintenance, and for short surgical procedures. Propofol is commonly used for both induction and maintenance anaesthesia.

  • They also reduce the number of some receptors, which may contribute to the therapeutic action, but their complete mechanism of action is unknown.
  • Pagets disease and osteoporosis are conditions where there is loss of normal bone tissue due to overactivity of osteoclasts.
  • Adverse effects include postural hypotension, bradycardia and fluid retention.
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Some had already implemented protocols as indicated in BNMS guidance but many had not complied with local medicines management arrangements for risk assessment and Trust approval. An informal discussion with the Department of Health confirmed that Trusts retain the right to approve or veto the adoption of legislation into working practice, amplifying the requirement to seek formal Trust approval prior to implementation.

However, bacteria, viruses and fungi are also parasitic, in that they live in or on other living organisms. The term parasite can be applied to any organism that causes disease. A basic knowledge of the characteristics of these organisms is needed in order to understand how they differ from human cells and how these differences can be exploited in chemotherapy. Bacteria are furosemide pill price cell organisms, which can be rod-shaped or spherical. Spherical bacteria are known as cocci, and they can be single or double, in strings or in clumps.

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Doxorubicin inhibits an enzyme called topoisomerase. During replication of DNA, this enzyme brings about swivelling of individual strands of DNA so they can be copied without becoming entangled in each other. Doxorubicin prevents this. Doxorubicin is used to treat leukaemia, lymphoma and many solid tumours. Apart from nausea and vomiting and bone marrow suppression, adverse effects with doxorubicin are cardiotoxicity and possibility of cardiac failure. Dactinomycin binds to guanine in DNA and prevents the movement of RNA polymerase, so interfering with protein synthesis.


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Examples of opioid analgesics are fentanyl and morphine.

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Drug therapy of anxiety is mainly with a group of drugs called benzodiazepines.

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