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Radioactive iodine is also used to treat thyrotoxicosis and to assess thyroid function. Eventually it causes hypothyroidism, which has to be treated by thyroid hormone replacement. Hyposecretion of thyroid hormone due to absence or incomplete development of the thyroid in early life causes cretinism, which is characterized by stunted growth and mental deficiency. Hyposecretion in adults results in myxoedema, a condition where there is a characteristic thickening of the skin together with low metabolic rate, slow speech, poor appetite, weight gain, lethargy, bradycardia, sensitivity to cold and mental impairment. One form is Hashimotos thyroiditis, an autoimmune condition where antibodies are produced against thyroglobulin. Treatment is by replacement therapy with thyroxine.

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