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Chemically, most drugs are either weak acids or weak bases. In an acidic environment, as in the stomach, acidic drugs are unionized according to the following simple equation: where A is an acidic drug and the excess hydrogen ions drive the equation to the left.
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Moritz
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Diuretics may also increase plasma lipid levels and cause glucose intolerance and insulin resistance, so they have to be used with caution in individuals with hyperlipidaemia andor diabetes.
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Bernhard
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