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Many drugs can be actively secreted by this mechanism, which increases their rate of removal from the body. Active transport does not depend on concentration gradients and can overcome plasma protein binding.

Authored by Andrew Teffeau, MD


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Chemically, most drugs are either weak acids or weak bases. In an acidic environment, as in the stomach, acidic drugs are unionized according to the following simple equation: where A is an acidic drug and the excess hydrogen ions drive the equation to the left.

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