Jentadueto XR is not for treatment of type 1 diabetes or diabetic ketoacidosis. Linagliptin is an orally-active inhibitor of the dipeptidyl peptidase -4 DPP-4 enzyme. Linagliptin is a white to yellowish, not or only slightly hygroscopic solid substance. It is very slightly soluble in water 0. Linagliptin is soluble in methanol ca. Coating: hydroxypropyl cellulose, hypromellose, talc, titanium dioxide, arginine, polyethylene glycol, ferric oxide yellow 2.

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Not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis, as it would not be effective in these settings. Has not been studied in patients with a history of pancreatitis; unknown whether patients with a history of pancreatitis are at an increased risk of developing pancreatitis when taking linagliptin. Renal impairment eg, eGFR Acute or chronic metabolic acidosis, including diabetic ketoacidosis; diabetic ketoacidosis should be treated with insulin. Use in combination with an insulin secretagogue eg, sulfonylurea was associated with a higher rate of hypoglycemia compared with placebo in a clinical trial. Cardiovascular collapse shock from whatever cause eg, acute congestive heart failure, acute myocardial infarction, and other conditions characterized by hypoxemia has been associated with lactic acidosis and may also cause prerenal azotemia; discontinue drug promptly. Heart failure has been observed with two other members of the DPP-4 inhibitor class; consider risks and benefits of empagliflozin in patients with risk factors for heart failure; monitor for signs and symptoms; if heart failure develops, manage accordingly to standard of care and consider interrupting treatment. Linagliptin: Dipeptidyl peptidase 4 DPP-4 inhibitor; increases and prolongs incretin hormone activity from glucagon-like peptide-1 GLP-1 and glucose-dependent insulinotropic polypeptide GIP which are inactivated by the DPP-4 enzyme; incretins increase insulin release and reduce glucagon secretion. Dosing should be individualized on the basis of both effectiveness and tolerability, while not exceeding the maximum recommended dose for either prompt-release or extended-release tablets. Your list will be saved and can be edited at any time.

Trajenta is indicated in adults with type 2 diabetes mellitus as an adjunct to diet and exercise to improve glycaemic control as The dose of linagliptin is 5 mg once daily. When linagliptin is used in combination with a sulphonylurea or linagliptin metformin price insulin, a lower dose of the sulphonylurea or insulin, may be considered to reduce the risk of hypoglycaemia see section 4. Pharmacokinetic studies suggest that no dose adjustment is required for patients with hepatic impairment but clinical experience in such patients is lacking. The safety and efficacy of linagliptin in children and adolescents has not yet been established. No data are available.

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Type 2 diabetes mellitus T2DM is a progressive condition requiring long-term treatment. Among the available DPP-4 inhibitors, linagliptin stands out as the only agent predominantly excreted through biliary pathways, making it suitable for patients with any degree of renal or liver impairment without dose adjustment. The ADA does not prioritize second-line agents, but stresses individualization of therapy. Linagliptin inhibits the DPP-4 enzyme, thus prolonging the half-life of the intestinal incretins, GLP-1 and gastric inhibitory polypeptide. This results in enhanced glucose-dependent insulin secretion and decreased glucagon production, leading to an overall improvement in glucose homeostasis both in the fasting and post-prandial state.

No meaningful change in body weight was noted in any treatment group. In initial therapy, the maximum dose of 2. It has not been studied in combination with insulin. Approximately Lactic acidosis is a medical emergency and must be treated in a hospital. Symptoms of low blood sugar include shaking, rapid heartbeat, hunger, headache, sweating, change in vision, and change in mood.

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