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The pathogenesis of GC is a complex, multifactorial process involving epigenetic alterations as well as tumor gene mutations 2. Although the prognosis for individuals diagnosed with GC has improved with advances in treatment strategies, the overall patient survival rate is still very poor 3. MicroRNAs miRNAs are a class of small non-coding RNAs that play a vital role in various physiological and pathological processes by negatively regulating the stability or translational efficiency of their target mRNAs 6. Abnormal miRNA expression level has been observed in a variety of diseases, particularly in cancer. MiR, which is found on chromosome 10, has an anti-oncogenic role and its expression is suppressed in multiple cancers including colorectal, breast, lung, and GCs 9 - A previous study demonstrated that miR over-expression inhibited proliferation and metastasis of GC cells, and that low miR expression level may serve as an effective biomarker for predicting poor disease prognosis in GC patients

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According to the Department of Health definition, a supplementary prescriber forms a voluntary partnership with an independent prescriber. A CMP is agreed with individual patient and the supplementary prescriber manages the patients clinical condition, including prescribing, according to the CMP. Supplementary prescribers have few restrictions on the medicines that they can prescribe. As long as the medicines can be prescribed by a doctor at NHS expense and are referred to in the patients CMP, they can be prescribed. Supplementary prescribers prescribe in partnership with a doctor.

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