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Adjunctive therapy to diet and exercise to improve glycemic control in adults with type 2 diabetes. Elderly patients are more likely to have decreased renal function; contraindicated in patients with renal impairment, carefully monitor renal function in the elderly and use with caution as age increases. Concomitant administration of insulin and insulin secretagogues e. Withholding of food and fluids during surgical or other procedures may increase risk for volume depletion, hypotension, and renal impairment; therapy should be temporarily discontinued while patients have restricted food and fluid intake. Not indicated for use in patients with type 1 diabetes mellitus that are insulin dependent due to lack of efficacy. Decreases hepatic glucose production; decreases GI glucose absorption; increases target cell insulin sensitivity. Remove bottle containing drug pellets and drug diluent bottle along with measuring cup from the box.
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JANUMET is indicated, as an adjunct to diet and glucophage 850 mg, to improve glycemic control in adults with type 2 diabetes mellitus. Prompt hemodialysis is recommended. In patients at increased risk for the development of renal impairment eg, the elderly, renal function should be assessed more frequently. Withholding of food and fluids during surgical or other procedures may increase the risk for volume depletion, hypotension, and renal impairment. Cardiovascular collapse shock, acute myocardial infarction, sepsis, and other conditions associated with hypoxemia have been associated with lactic acidosis and may also cause prerenal azotemia. An association between dipeptidyl peptidase-4 DPP-4 inhibitor treatment and heart failure has been observed in cardiovascular outcomes trials for two other members of the DPP-4 inhibitor class.
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UK Edition. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
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Spectral data of the tissue spots in the test sets were collected and analyzed exactly the same way the training set tissue spots were treated, and a test set of spectra was created. Strong CYP3A4 inhibi- tors like fluconazole may greatly increase serum concentrations of aripiprazole, and it is important to reduce aripiprazole doses by half in patients who receive both agents.
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Overdose occurs when plasma levels of local anaesthetic are such that systemic effects appear.
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Blood flow in other organs tends to remain constant. This could alter expected drug distribution.
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