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In addition, serum markers of disease progression are reduced. For many of these drugs the mode of action is not fully understood, but they all interfere with the activity of cells of the immune system in one way or another.

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Such combinations of drugs reduce the development of drug resistance in the virus. Fungi are multicellular or single cell organisms abundant in the environment; many live in association with humans without causing disease but some of them can be pathogenic in certain circumstances.

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This chapter gives a general overview of the endocrine system. Some detail is given of the thyroid gland, the adrenal glands, the pancreas and disorders of them because health care professionals are likely to come across patients with such disorders.

Drugs injected subcutaneously or intramuscularly have to diffuse between loose connective tissue or muscle fibres. The rate of absorption depends on the usual parameters for passage across cell membranes but also on the blood or lymphatic supply to a particular region. Increasing the blood supply by applying heat or massage will increase the rate of absorption. Conversely, for a local effect, addition of a vasoconstrictor to the injection decreases the rate of removal of the drug from the site of injection. Depot preparations are designed to give a slow sustained release of drug.

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The dose should then gradually be reduced to the lowest maintenance level that will control the disease or, if possible, discontinued altogether. This approach carries the risk that relapse may buy lunesta online as the dose is reduced, particularly if this is done too quickly. In order to avoid this relapse, the dose is often increased again and maintained. The danger then is that the patient becomes dependent on corticosteroids. Sometimes pulse doses of corticosteroids are used to suppress inflammation while longer term and slower acting DMARDs are being started. Corticosteroids suppress all phases of the inflammatory response, including the early swelling, redness and pain and the later stages seen in chronic inflammation.


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Myasthenia gravis is an autoimmune disease where acetylcholine receptors at the neuromuscular junction are progressively destroyed.

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The study of the effects that drugs can have on the body and how they produce these effects is known as pharmacodynamics.

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