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There are several techniques used to administer local anaesthetics, which are briefly described below. The first three are techniques that can be used by podiatrists in the course of their professional practice providing they are registered with the Health Professions Council and hold a certificate of competence in the use and administration of local anaesthetics.
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In order for tumours to grow they need to develop a blood supply. Drugs are being developed that inhibit angiogenesis, which is the growth of new blood vessels.
ACE inhibitors and angiotensin II receptor inhibitors limit the action of angiotensin II and suppress aldosterone production. These effects have benefits in the treatment of cardiac failure and hypertension because the resulting vasodilation and water loss lowers blood pressure. Ischaemic heart disease can be treated with nitrates, potassium channel activators, β-blockers and calcium channel blockers. All these drugs either improve the blood supply to the myocardium or reduce its metabolic demand for oxygen, or both. Beta blockers are also useful in treating hypertensive patients who do not respond adequately to other antihypertensive drugs, and some types of arrhythmia because they slow the heart rate.
This technique is used in obstetrics and genito-urinary surgery and is also known as intrathecal block. The anaesthetic is injected into the subarachnoid space via a lumbar puncture between vertebrae L Efferent nerves are affected by the local anaesthetic. This method carries a risk of damage to the spinal cord. This technique is similar to spinal anaesthesia. It is technically more difficult but is considered to be safer and has largely replaced spinal anaesthesia. The local anaesthetic is introduced into the extradural space between the bone of the spine and the dura mater, which is filled with fatty tissue and blood vessels.
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Cardiac glycosides are useful in cardiac failure and arrhythmias because they improve myocardial contractility and slow conduction through the heart. Diuretics encourage water loss from the body and this helps reduce circulating blood volume.
30.04.2020
Erhard
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However, because cancer cells are similar to normal cells, chemotherapy is toxic to rapidly dividing cells in bone marrow, hair follicles and the gastrointestinal tract. Resistance to cancer chemotherapy can occur and for this reason combinations of drugs with different mechanisms of action provide the best chance of a successful cure.
19.10.2018
Sofia
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