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Clotting factors circulate in an inactive form.
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Moreover, like antiepileptic drugs, local anaesthetics show use dependence in that they preferentially block neurons that are transmitting impulses at high frequency (as pain sensory neurons do).
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Mutated cells of this type may be resistant to drugs because they can survive DNA damage. Cells are stimulated to divide by growth factors, which form part of the cell cycle control system.
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