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Pansini 5, Naples, Italy. Doxycycline is used to treat infective diseases because of its broadspectrum efficacy. Three experimental settings were used, differing in the timing of doxycycline treatment in respect to the insult induced by LPS: pretreatment, concomitant, and posttreatment. The parent compound chlortetracycline was first isolated from Streptomyces aureofaciens in. Since then, the manipulation of natural antibiotics and the laboratory synthesis of novel compounds have enriched the tetracycline family.
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