The concordance rate for monozygotic twins is complex and likely to be an interaction between several genes and environmental factors. In schizophrenia, there appears to be overactivity of dopamine systems in areas of the brain associated with complex mental and emotional functions. This is the dopamine hypothesis of schizophrenia. There are four main neuronal systems in the brain in which dopamine is a transmitter: the basal nuclei; the hypothalamic-pituitary pathway and the mesolimbic and mesocortical pathways. A basic knowledge of these systems helps to understand how anti-psychotic drugs work and why they produce certain side effects.

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This increased drug usage in the elderly can give rise to a number of problems. Drugdrug interaction This occurs when two or more drugs, being taken concurrently, produce a pharmacological response not attributable to a single drug. The practice of multiple drug prescribing is known as polypharmacy. The more drugs being taken together the greater the risk of drugdrug interactions becomes.

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The pharmacology content of the training courses will include general principles of pharmacology: absorption, distribution, metabolism and excretion; individual variation to drug therapy, adverse drug reactions, drugdrug interactions, interactions with other diseases and drug interaction with receptors and the legal basis for prescribing, supply and administration of medicines, including regulatory aspects of controlled drugs. Employers are expected to recognize the need for private study time and to generally provide support. Training for supplementary prescribing is now incorporated into nurse and pharmacist independent prescribing as multidisciplinary training.

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POther factors to take into consideration are whether sedation is resistant and how susceptible the effective is to Parkinsonian side effects. Presumably drugs are more likely at relieving the positive symptoms and all provide better results in substantial schizophrenia. Long-term treatment may be complicated to prevent relapse and basic illness. p pWithdrawal of effective must be cautious to have relapse.

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