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As a group they are characterized by increased activity of phagocytes and the release of inflammatory mediators, which cause tissue damage. In diseases that primarily affect the joints there is inflammation and proliferation of cells of the synovial membrane and damage to cartilage and bone, but other connective tissues and organs in the body can also be damaged.

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Griseofulvin interacts with microtubules in fungal cells preventing the formation of the spindle during mitosis. It can be used topically and orally to treat skin and nail infections.

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