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Doxorubicin inhibits an enzyme called topoisomerase. During replication of DNA, this enzyme brings about swivelling of individual strands of DNA so they can be copied without becoming entangled in each other. Doxorubicin prevents this.
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They seem to increase glucose uptake by peripheral muscle cells and reduce gluconeogenesis and intestinal glucose absorption. Only one, metformin, is available in the United Kingdom.
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