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Renin together with angiotensin-converting enzyme produces angiotensin II, which is a powerful vasoconstrictor and stimulates the release of aldosterone from the adrenal glands. Figure shows the renin-angiotensin-aldosterone pathway. Vasoconstriction and the salt and water reabsorption activity of aldosterone result in restoration of blood volume and therefore blood pressure. In cardiac failure, cardiac output is reduced. This means initially that with exercise the organs and tissues do not have an adequate blood supply.
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Although the lungs are the major site of infection, the organism can also infect other tissues such as bones, joints and the brain. In the lungs, mycobacteria infect alveolar macrophages and this initiates an inflammatory reaction that involves many of the cells of the immune system.
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The metabolism of many drugs is directly proportional to the rate of blood flow through the liver; that is they exhibit flow-dependent hepatic clearance.
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Most tissues in the body have the enzymes capable of metabolizing a variety of substances.
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These are the International Classification of Diseases (ICD- Revised. With these systems, a diagnosis of mental disorders is made from the presence of specific symptoms or a syndrome for a minimum of two weeks.
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There are many disorders of the CNS. Psychiatric disorders include types of depression, psychosis and anxiety.
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