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Distribution can also be affected due to differences in body composition and the availability of plasma proteins for binding. At these extremes of life, drugs tend to produce greater and more prolonged effects. Many disease states can cause individual variation in response to drugs.
Nevertheless, alteration of stomach pH can alter the absorption characteristics of acidic drugs. A few drug molecules are small enough to diffuse through aqueous pores in the cell membrane with water, for example alcohol. However, the majority of drugs are too generic klonopin pink to diffuse in this way. Many nutrients and a few drugs can pass across the cell membrane by facilitated diffusion. In this case, in addition to the concentration gradient, a membrane protein acts as a carrier to transport a substance from one side of the membrane to the other.
Authored by Bob Green, MD
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