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Butyrophenones are of particular use for the rapid control of hyperactive states and in older people because they are less likely to cause a drop in blood pressure. An example is haloperidol.

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Because of this low toxicity, they are used most often nowadays, although monomeric, ionic meglumine ioxaglate is said to cause less pain and heat on injection.

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Local anaesthetics can affect both autonomic nerves and the neuromuscular junction.

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