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Adverse reactions to contrast agents can range from trivial skin rashes to life-threatening anaphylaxis. The commonest side effects are nausea and vomiting and hypersensitivity with intravenous use. High osmolality causes dehydration of red blood cells and increases the risk of thrombosis and causes vasodilation and sensation of heat on injection. Ionization can adversely affect the heart and central nervous system and may cause allergic reactions. Entry of contrast agent into the central nervous system is unlikely unless the integrity of the bloodbrain barrier has been compromised by the osmotic effects of the contrast agent. Dehydration of endothelial cells of brain capillaries may allow diffusion of contrast agent into the brain.

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In order to have an effect on the body, therapeutic, adverse or otherwise, a drug must interact with its site of action.

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Historically, the development of antiviral drugs has been slow when compared with the development of other antimicrobial drugs. This was probably because the majority of viral infections are eliminated by the hosts immune system.

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Thiopental is an anaesthetic but has no analgesic action; indeed, it may increase perception of pain. Because thiopental causes myocardial and respiratory depression and has a very narrow margin of safety, it has been largely superseded by non-barbiturates.

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This is combined with an especially close cooperative approach to the management of foot pathology, which includes general practitioners and other medical specialists, other podiatrists, physiotherapists and crucially the patients themselves in working towards their cure or improvement. The Health Professions Council is the statutory body responsible for the registration of podiatrists in the United Kingdom.

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